Key result
High-intensity interval training reduces PTX3, VCAM-1, and CRP in rats with metabolic syndrome.
Why the study?
Sedentary lifestyle and lack of exercise cause cardiovascular diseases and metabolic syndrome, but the effects of interval training on inflammatory markers in metabolic syndrome are unclear.
Does interval training reduce inflammatory markers (PTX3, VCAM-1, and CRP) in rats with metabolic syndrome?
Does interval training reduce inflammatory markers (PTX3, VCAM-1, and CRP) in rats with metabolic syndrome?
p-value: p=0.034, 0.027, and 0.021
High-intensity interval training significantly reduces inflammatory markers (PTX3, VCAM-1, CRP) in a rat model of fructose-induced metabolic syndrome.
HIIT may attenuate inflammation in metabolic syndrome models; hypothesis-generating, leaves open human translation.
Background: Sedentary lifestyle and lack of exercise cause cardiovascular diseases and metabolic syndrome. Decreased movement in recent decades has caused cardiovascular diseases. Methods: In this research, 35 male Wistar rats weighing 220 ± 20 g were divided into 5 groups (seven rats in each group) by a simple random method. The first and second experimental groups were given 100 grams per liter of fructose with water for 6 weeks, and the third experimental group received this for 14 weeks. The training group performed the interval training protocol on the treadmill for eight weeks and 5 days a week. One-way analysis of variance (ANOVA) was used to compare the groups. Results: The use of the fructose diet for 6 weeks and 14 weeks caused metabolic syndrome in male Wistar rats. Induction of metabolic syndrome increased the plasma levels of PTX3, VACM-1, and CRP at the end of 6 weeks (P = 0.001, P = 0.018, and P = 0.004, respectively) and the fourteenth week (P = 0.001, P = 0.001, and P = 0.001, respectively). Eight weeks of interval training significantly reduced PTX3, VACM-1, and CRP (P = 0.034, P = 0.027 and P = 0.021, respectively). Conclusions: The fructose diet caused metabolic syndrome and a significant increase in inflammatory markers in rats, and high-intensity interval training significantly reduced inflammatory factors in them.
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Valinejad et al. (2023) studied Metabolic syndrome (n=35). High-intensity interval training vs. Fructose diet without exercise was evaluated on Plasma levels of PTX3, VCAM-1, and CRP (p=0.034, 0.027, and 0.021). Eight weeks of high-intensity interval training significantly reduced plasma levels of PTX3, VCAM-1, and CRP in rats with fructose-induced metabolic syndrome.
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