Key result
Donor nephrectomy linked to higher serum creatinine and masked hypertension in 10% of donors.
Why the study?
The significance of post-nephrectomy hypertension and increasing proteinuria in transplant donors needs further evaluation.
Does donor nephrectomy impact blood pressure and renal function in transplant donors?
Observational (n=51)
Does donor nephrectomy impact blood pressure and renal function in transplant donors?
Ambulatory blood pressure monitoring is superior to routine office blood pressure monitoring for detecting masked hypertension in kidney donors post-nephrectomy.
Answers are grounded in this paper and cite their sources.
Living kidney donation linked to post-donation proteinuria and creatinine rise, especially in donors >55; leaves open long-term risk stratification needs.
= 0.02). Median pre-nephrectomy proteinuria was 70 mg (10 mg-180 mg) with a mean estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease (MDRD) formula of 86.86 ± 19.1 ml/min. Six donors developed >300 mg/day proteinuria, and 17 (33.3%) had a 24-hour urinary protein excretion greater than 150 mg/day. Mean serum creatinine (0.79 ± 0.11 vs 1.03 ± 0.16 mg/dl) significantly increased post donation, more so in donors >55 years of age (1.14 ± 0.25 mg/dl). Our study shows that in transplant donors, ABPM is better for diagnosing hypertension, which otherwise remains masked in 10% of the donors on routine OBPM. Significance of post-nephrectomy hypertension and increasing proteinuria needs further evaluation.
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Bhowmik et al. (2019) conducted an observational in Transplant donors (n=51). Donor nephrectomy vs. Pre-nephrectomy baseline was evaluated on Mean serum creatinine (mg/dl). Donor nephrectomy increased mean serum creatinine, and ambulatory blood pressure monitoring identified masked hypertension in 10% of donors.
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