Key result
Outpatient anesthesia triggers delayed malignant hyperthermia causing severe AKI and rhabdomyolysis in a 73-year-old man.
Why the study?
Malignant hyperthermia can present with variable symptoms and delayed onset, making definitive diagnosis challenging outside the intraoperative setting.
Case Report (n=1)
Delayed onset malignant hyperthermia can present atypically with severe oliguria and rhabdomyolysis, requiring high clinical suspicion by internists.
Alerts internists to atypical delayed malignant hyperthermia in post-anesthesia rhabdomyolysis; single case leaves broader incidence open.
Malignant hyperthermia (MH) is a rare but potentially life threatening drug related reaction predisposed by genetic factors. Although most cases develop within the intraoperative setting, less commonly, delayed onset presentations have also been reported. With variability in symptoms and time of onset, definitive diagnosis of MH is challenging. Herein, we report a case of a 73-year-old man presented with severe oliguria in the setting of recent surgical procedure. He was found to have acute kidney injury, myoglobinuria, transaminitis and elevated CPK indicative of rhabdomyolysis.
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A et al. (2020) conducted a case report in Delayed onset malignant hyperthermia (n=1). Anesthesia exposure was evaluated. A 73-year-old man developed severe oliguria, acute kidney injury, and rhabdomyolysis due to delayed onset malignant hyperthermia after receiving anesthesia for an outpatient laryngoscopy.
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