Key result
First-trimester sertraline use linked to ~36% greater risk of infant cardiovascular malformations.
Why the study?
The association between sertraline use in the first trimester of pregnancy and the risk of congenital anomalies in infants was uncertain.
Does sertraline use in the first trimester increase the risk of congenital anomalies in infants?
Meta-Analysis (n=6,468,241)
Does sertraline use in the first trimester increase the risk of congenital anomalies in infants?
Odds Ratio: 1.36 (95% CI 1.06–1.74)
Sertraline use during the first trimester of pregnancy is associated with a significantly increased risk of cardiovascular-related malformations, including atrial and ventricular septal defects, in infants.
Sertraline in first trimester was associated with higher cardiovascular malformation odds; leaves open confounding and needs prospective confirmation before practice change.
Aim To perform a meta‐analysis of available cohort studies on the association between sertraline use by pregnant women in the first trimester and the findings of congenital anomalies in infants. Methods A comprehensive search of articles published from the index date up to 31st December 2015 investigating the aforementioned associations was conducted on PubMed and Web of Science. Mesh headings used included the terms “serotonin reuptake inhibitor,” “sertraline,” “congenital anomalies” and “obstetrical outcome.” Results Twelve cohort studies that involved 6 468 241 pregnant women were identified. We summarized odds ratios (ORs) and 95% confidence intervals (CIs) of congenital anomalies using the random‐effects model. Pregnant women who used sertraline in the first trimester had a statistically significant increased risk of infant cardiovascular‐related malformations (OR = 1.36; 95% CI = 1.06–1.74; I2 = 64.4%; n = 12) as well as atrial and/or ventricular septal defects (OR = 1.36, 95% CI = 1.06–1.76; I2 = 62.2%; n = 8). Additionally, positive but nonsignificant associations between sertraline use and congenital anomalies of the nervous system (OR = 1.39; 95% CI = 0.83–2.32; I2 = 0%; n = 5), digestive system (OR = 1.23; 95% CI = 0.76–1.98; I2 = 0%; n = 5), eye, ear, face and neck (OR = 1.08; 95% CI = 0.33–3.55; I2 = 32.1%; n = 3), urogenital system (OR = 1.03; 95% CI = 0.73–1.46; I2 = 0%; n = 5), and musculoskeletal system (OR = 0.97; 95% CI = 0.69–1.36; I2 = 0%; n = 5) were observed. Conclusion This meta‐analysis suggested that the use of sertraline use by pregnant women in the first trimester had an increased risk of cardiovascular‐related malformations as well as atrial and/or ventricular septal defects in infants. Meanwhile, nonsignificant associations between sertraline use and other congenital anomalies were found. More cohort studies are warranted to provide detailed results of other congenital anomalies.
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Shen et al. (2016) conducted a meta-analysis in Pregnancy (n=6,468,241). Sertraline vs. No sertraline use was evaluated on Infant cardiovascular-related malformations (OR 1.36, 95% CI 1.06-1.74). First-trimester sertraline use by pregnant women was associated with an increased risk of infant cardiovascular-related malformations (OR 1.36; 95% CI 1.06-1.74).
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