Key result
Neurovirulent influenza A and potent viruses are hypothesized to drive Parkinson's disease via Lewy body formation.
Why the study?
Some clinical reports and epidemiological data suggest a viral role in the etiology of Parkinson's disease, but direct detection of viruses in patients has been generally unsuccessful.
Design
Review
Authors
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Hypothesis-generating for viral triggers in PD; leaves open any clinical relevance pending higher-level evidence.
Proposes a hypothesis linking neurovirulent influenza A and other viruses to the formation of Lewy bodies and neuronal death in Parkinson's disease.
Takahashi et al. (1999) conducted a review in Parkinson's disease. Viral infection (influenza A virus) was evaluated. Neurovirulent influenza A virus and other potent viruses are hypothesized to be responsible for the formation of Lewy bodies and the death of nigral neurons, constituting a viral etiology for Parkinson's disease.
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