Intravenously administered glycerol rapidly disappears from the bloodstream. Single injections of 6 g glycerol did not produce excessive urinary excretion of glycerol but 12 g led to excretion of one-third the dose. Daily infusions of large doses of glycerol produced marked polyuria and in some animals led to tremors and convulsions. These disturbances were not caused by accumulation of glycerol in the blood.
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Zilversmit et al. (1957) studied this question.