Key result
LDL, homocysteine, and TC/HDL ratio strongly predict CAD risk with ~97% explanatory power.
Why the study?
The study aimed to compare levels of traditional and emerging biomarkers in CAD patients versus controls to better understand risk factors associated with CAD.
Are biomarkers such as homocysteine, lipid profile, HS-CRP, ADMA, and apolipoproteins associated with the presence of coronary artery disease?
Case-Control (n=200)
Are biomarkers such as homocysteine, lipid profile, HS-CRP, ADMA, and apolipoproteins associated with the presence of coronary artery disease?
Effect estimate: R² = 97.2%
LDL, homocysteine, and the TC/HDL ratio are strong biomarker predictors of coronary artery disease risk.
May inform CAD risk stratification; hypothesis-generating and requires prospective validation before clinical adoption.
A BSTRACT Introduction: Coronary artery disease (CAD), resulting from the narrowing of coronary arteries that supply oxygen to the heart, poses a significant global health challenge. Materials and Methods: To compare the levels of homocysteine, lipid profile, lipid ratios, HS-CRP, ADMA, and apolipoproteins in CAD patients with controls, this chapter analyzes risk factors, biomarkers, and clinical traits linked to coronary artery disease (CAD) through a case–control study involving 200 participants (100 CAD cases and 100 controls). The investigation focuses on demographic variables, traditional risk factors (e.g., hypertension, smoking, alcohol intake), and essential biochemical markers such as lipid profiles, homocysteine, and emerging biomarkers like HS-CRP, ADMA, and apolipoproteins (Apo A1 and Apo B). Results and Conclusion: The findings underscore the interplay between traditional and emerging risk factors in CAD progression. LDL, homocysteine, and TC/HDL ratio emerge as robust predictors of CAD risk. The regression model’s high explanatory power (R ² =97.2%) validates these indicators for effective risk assessment.
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Singh et al. (2025) conducted a case-control in Coronary artery disease (CAD) (n=200). Biomarkers (LDL, homocysteine, TC/HDL ratio, HS-CRP, ADMA, apolipoproteins) vs. Controls was evaluated on CAD risk (R² = 97.2%). LDL, homocysteine, and TC/HDL ratio emerged as robust predictors of CAD risk, with the regression model demonstrating a high explanatory power (R² = 97.2%).
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