Traditional and Alternative Treatments for Depression: Implications for Migraine Management

BACKGROUND: Migraine is frequently comorbid with major depressive disorder, the presence of which confers increased disability and various clinical challenges. METHODS/RESULTS: The present article reviews empirically supported pharmacologic and cognitive-behavioral interventions for depression, as well as the emerging yet generally mixed efficacy for various complementary and alternative medicine depression treatments. DISCUSSION AND CONCLUSION: Clinical implications and treatment strategies for migraine patients with comorbid depression are discussed. The literature reviewed here draws together clinical practice options for clinicians.