Impact of Sex Difference on the Discordance of Revascularization Decision Making Between Fractional Flow Reserve and Diastolic Pressure Ratio During the Wave‐Free Period

Figures

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  Figure 1. Sex difference in fractional flow reserve (FFR)–diastolic pressure ratio during the diastolic wave‐free period (dPRWFP) categorization. Lesions were categorized into 4 groups according to FFR and dPRWFP. Group 1 included lesions with FFR >0.80 and dPRWFP >0.89 (FFR− dPR−); group 2, FFR ≤0.80 and dPRWFP >0.89 (FFR+ dPR−); group 3, FFR >0.80 and dPRWFP ≤0.89 (FFR− dPR+); and group 4, FFR ≤0.80 and dPRWFP ≤0.89 (FFR− dPR+). Discordance was observed in 183 lesions (24.1%). Proportions shown in each group of the top panel indicate the proportion of the number of the lesion in the group to the total number in women (orange bar) and men (blue bar). Prevalence of group 2 was greater in women than in men. *: A significant difference between women and men (p<0.05).

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  Figure 2. Frequency of positive fractional flow reserve (FFR) and FFR value in each diastolic pressure ratio during the diastolic wave‐free period (dPRWFP) quartile (Q). Top: The frequency of positive FFR in women and men in each dPRWFP Q. FFR was significantly less frequently positive (≤0.80) in women in the second and third Qs (0.83–0.93) of dPRWFP. Bottom: Comparison of FFR values between sexes in each dPRWFP Q. FFR was higher in women than in men in all dPRWFP Qs.

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  Figure 3. Frequency of positive diastolic pressure ratio during the diastolic wave‐free period (dPRWFP) and dPRWFP value in each fractional flow reserve (FFR) quartile (Q). Top: The frequency of positive dPRWFP in women and men in each FFR Q. Positive dPRWFP showed nonsignificant trend toward a higher frequency in women than in men. Bottom: The comparison of dPRWFP value between sexes in each FFR Q. dPRWFP was lower in the second and fourth Qs.

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  Figure 4. Scattergrams and linear regression lines between fractional flow reserve (FFR) and diastolic pressure ratio during the diastolic wave‐free period (dPRWFP) in men and women. Linear regression lines with 95% CIs for men and women are depicted. The regression line for women is located below that for men, which indicates the distribution shift to higher FFR and lower dPRWFP. Two lines were separated in the middle of the chart, whereas there were overlaps between the 2 lines in both ends of the chart. The middle part of the chart around FFR 0.80 is magnified in the right panel. The reference line of FFR 0.80 (black line) and the corresponding points for men (blue dashed line) and for women (red dashed line) are overlaid.