Key result
Oral nitazoxanide shortens acute rotavirus diarrhea by ~26 hours vs standard treatment.
Why the study?
Acute diarrhea is a leading cause of childhood mortality with rotavirus as an important pathogen, and the role of nitazoxanide in acute rotavirus diarrhea needed evaluation.
Does nitazoxanide reduce the duration of diarrhea in children with acute rotavirus diarrhea?
RCT (n=50)
Double-blind
randomized
Does nitazoxanide reduce the duration of diarrhea in children with acute rotavirus diarrhea?
Mean Difference: -26 (95% CI -38.8–-13.2)
Absolute Event Rate: 54% vs 80%
Oral nitazoxanide significantly reduces the duration of diarrhea and hospitalization in children with acute rotavirus diarrhea.
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Supports nitazoxanide addition to standard care for pediatric rotavirus diarrhea; confirms RCT efficacy and extends evidence for antiviral adjuncts.
Mahapatro et al. (2017) conducted an RCT in Acute rotavirus diarrhea (n=50). Nitazoxanide vs. Standard treatment was evaluated on Duration of diarrhea (MD -26, 95% CI -38.8 to -13.2). Oral nitazoxanide significantly reduced the median duration of acute rotavirus diarrhea compared to standard treatment (54 vs 80 hours; MD -26, 95% CI -38.8 to -13.2).
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