What question did this study set out to answer?

To evaluate whether adding theophylline to low-dose beclomethasone dipropionate provides clinical outcomes equivalent to doubling the inhaled steroid dose in patients with asthma symptomatic on low-dose therapy.

December 1, 1997European Respiratory JournalOpen Access

Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma

View Full Paper

Ask AI

Bookmark

Authors

DUD. UkenaNational Institutes of Health UHUlf HarnestMunich Business School RSRaimundas SakalauskasSemmelweis University

Discussion

Member takes

Implication

Randomized double-blind trial shows similar efficacy between add-on theophylline and doubled inhaled steroid in symptomatic asthma, indicating theophylline works as a steroid-sparing option.

Key Points

To evaluate whether adding theophylline to low-dose beclomethasone dipropionate provides clinical outcomes equivalent to doubling the inhaled steroid dose in patients with asthma symptomatic on low-dose therapy.
Conducted a randomized, double-blind, parallel-group trial across multiple European centers involving asthmatic patients symptomatic on beclomethasone dipropionate (BDP) 400 µg/day.
Assigned participants to 6 weeks of treatment with either oral theophylline plus BDP 400 µg/day (n=69; mean serum concentration 10.1 ± 4.2 mg/L) or doubled BDP at 800 µg/day (n=64).
Assessed lung function via forced expiratory volume in one second (FEV1), daily peak expiratory flow (PEF), symptom scores, and rescue salbutamol use.
Both treatment regimens produced significant increases in FEV1 and PEF at week 6 (p<0.01), accompanied by an approximate 30% reduction in PEF variability in both groups.
Asthma symptoms and rescue salbutamol usage declined significantly across both arms (p<0.001), with no statistically significant differences observed between the two treatments.

Cite This Study

Ukena et al. (1997) studied this question.

synapsesocial.com/papers/6aaf39cc4669f260a83983ff https://doi.org/10.1183/09031936.97.10122754

View Full Paper

Ask AI

Bookmark

Implication

Randomized double-blind trial shows similar efficacy between add-on theophylline and doubled inhaled steroid in symptomatic asthma, indicating theophylline works as a steroid-sparing option.

Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider