Key result
Diagnostics identify a pathogen in ~38% of adult CNS infections, primarily Japanese encephalitis and enteroviruses.
Why the study?
The pathogens causing central nervous system infections in adults in Kathmandu, Nepal were not well characterized using molecular and serology methods.
Observational (n=87)
No
This study demonstrates that Japanese encephalitis virus and enteroviruses are the most common identifiable causes of central nervous system infections among adults in Kathmandu, Nepal.
Etiological diagnosis achieved in only 38% of adult CNS infections; leaves open the need for improved diagnostics and regional pathogen surveillance.
We conducted a prospective hospital based study from February 2009-April 2011 to identify the possible pathogens of central nervous system (CNS) infections in adults admitted to a tertiary referral hospital (Patan Hospital) in Kathmandu, Nepal. The pathogens of CNS infections were confirmed in cerebrospinal fluid (CSF) using molecular diagnostics, culture (bacteria) and serology. 87 patients were recruited for the study and the etiological diagnosis was established in 38% (n = 33). The bacterial pathogens identified were Neisseria meningitidis (n = 6); Streptococcus pneumoniae (n = 5) and Staphylococcus aureus (n = 2) in 13/87(14%). Enteroviruses were found in 12/87 (13%); Herpes Simplex virus (HSV) in 2/87(2%). IgM against Japanese encephalitis virus (JEV) was detected in the CSF of 11/73 (15%) tested samples. This is the first prospective molecular and serology based CSF analysis in adults with CNS infections in Kathmandu, Nepal. JEV and enteroviruses were the most commonly detected pathogens in this setting.
No takes yet. Share an insight, caveat, or question.
Giri et al. (2013) conducted an observational in Central Nervous System (CNS) infections (n=87). Central Nervous System infections was evaluated on Etiological diagnosis of CNS infections. An etiological diagnosis was established in 38% of adults with CNS infections, with Japanese encephalitis virus (15%) and enteroviruses (13%) being the most commonly detected pathogens.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: