What is the clinical evidence from this study?

Study design: Other. Population: Ischemia/Reperfusion-Induced Acute Kidney Injury (n=21). Intervention: Tilianin vs. Vehicle (DMSO and corn oil). Primary outcome: Kidney function (Scr and BUN) and apoptosis.

What does this research mean for the field?

Tilianin improves kidney function and reduces apoptosis in ischemia/reperfusion-induced acute kidney injury via regulation of the ERK/EGR1/BCL2L1 pathway. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 3, 2022Frontiers in PharmacologyOpen Access

Tilianin Reduces Apoptosis via the ERK/EGR1/BCL2L1 Pathway in Ischemia/Reperfusion-Induced Acute Kidney Injury Mice

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Key result

Tilianin improves kidney function and reduces apoptosis in AKI mice via the ERK/EGR1/BCL2L1 pathway.

n=21

Why the study?

Tilianin has been reported to alleviate myocardial ischemia/reperfusion injury, but its effect on ischemia/reperfusion-induced acute kidney injury was unknown.

Population

Ischemia/reperfusion-induced acute kidney injury mouse models

Comparison

Tilianin treatment vs no tilianin treatment

Design

Bioinformatics analysis combined with in vivo experimental study

Authors

ZLZengying LiuQingdao University GCGuan ChenQingdao University CLChenyu LiQingdao University

Discussion

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Implication

Tilianin merits further preclinical testing in AKI; hypothesis-generating and should not yet influence clinical practice.

PICO

Population

21 male C57BL/6 mice aged 6-8 weeks subjected to ischemia/reperfusion-induced acute kidney injury.

Intervention / Comparator

Tilianin vs Vehicle (DMSO and corn oil) (5, 10, and 15 mg/kg)

Primary Outcome

Kidney function (Scr and BUN) and apoptosis

Limitations

ERK1/2 and EGR1 may not be the only molecules involved in tilianin-mediated renoprotection
Binding between tilianin and ERK1/2 or p-ERK could not be fully confirmed
Other effects of tilianin such as antioxidant and anti-inflammatory properties were not fully explored

Cite This Study

Liu et al. (2022) studied Ischemia/Reperfusion-Induced Acute Kidney Injury (n=21). Tilianin vs. Vehicle (DMSO and corn oil) was evaluated on Kidney function (Scr and BUN) and apoptosis. Tilianin improved kidney function and reduced apoptosis in ischemia/reperfusion-induced acute kidney injury mice by attenuating the ERK/EGR1/BCL2L1 pathway.

synapsesocial.com/papers/6aaf3a817e8385fbd3d05f98 https://doi.org/10.3389/fphar.2022.862584

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Tilianin Reduces Apoptosis via the ERK/EGR1/BCL2L1 Pathway in Ischemia/Reperfusion-Induced Acute Kidney Injury Mice

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

Tilianin Reduces Apoptosis via the ERK/EGR1/BCL2L1 Pathway in Ischemia/Reperfusion-Induced Acute Kidney Injury Mice

Discussion

Member takes

Implication

PICO

Limitations

Cite This Study

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