Key result
Chuanxiong extracts lower whole blood viscosity ~18% in a rat model of acute blood stasis.
Why the study?
The active ingredients of Chuanxiong responsible for promoting blood circulation and removing blood stasis were not clearly identified.
Five active components of Chuanxiong, particularly when extracted with dichloromethane, significantly improve hemorheology indices in a rat model of blood stasis.
Should not yet change practice; leaves open human translation of Chuanxiong dichloromethane fraction for hemorheologic disorders.
Purpose: To study the active ingredients of Chuanxiong (CX) in promoting blood circulation and removing blood stasis. Methods: Blood-activating effects and serum HPLC fingerprints of CX extracts from different parts of China were studied and the spectrum-effect relationship between them was established by grey correlation analysis. Results: After treatment with CX extracted using different solvents, hemorheology indices were lower than those in the model group, and the effect of dichloromethane was better than that of other solvents (p < 0.05 or p < 0.01). There were 6 common peaks by fingerprint analysis. Peaks 1 - 5 were identified as senkyunolide I, senkyunolide H, senkyunolide A, coniferyl ferulate and ligustilide, respectively. Conclusion: Analysis of the spectrum–effect relationship indicates the contribution of the five components to the blood-activating effect of CX. The findings lend some scientific justification for using CX to remove blood stasis, and selection of quality evaluation indices for CX.
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Chen et al. (2022) studied Acute blood stasis. Chuanxiong (CX) extracts vs. Model group (pure water) was evaluated on Whole blood viscosity at 200 s-1 (p=<0.01). Chuanxiong extracts, particularly the dichloromethane fraction, significantly improved hemorheology indices in a rat model of acute blood stasis, with five components including senkyunolide I identified as key active ingredients.
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