Key result
Cellular mechanisms modulate co-translational protein folding and translation to optimize protein biosynthesis.
Why the study?
Co-translational protein folding is essential for proper protein biosynthesis, but the mechanisms regulating folding and translation coupling remain to be fully understood.
This review highlights recent progress in understanding the mechanisms and regulation of co-translational protein folding on the ribosome.
Advances mechanistic understanding of protein biosynthesis; leaves open therapeutic targeting in folding disorders.
Co-translational protein folding is an essential process by which cells ensure the safe and efficient production and assembly of new proteins in their functional native states following biosynthesis on the ribosome. In this review, we describe recent progress in probing the changes during protein synthesis of the free energy landscapes that underlie co-translational folding and discuss the critical coupling between these landscapes and the rate of translation that ultimately determines the success or otherwise of the folding process. Recent developments have revealed a variety of mechanisms by which both folding and translation can be modulated or regulated, and we discuss how these effects are utilised by the cell to optimise the outcome of protein biosynthesis.
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Waudby et al. (2019) conducted a review in Co-translational protein folding. Recent developments reveal various mechanisms by which co-translational protein folding and translation can be modulated or regulated by the cell to optimize the outcome of protein biosynthesis.
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