October 1, 1987Allergy
Diminished atherosclerotic arterial calcifications in asthma
Key result
Asthma in patients over 50 is linked to less calcified aortic and pelvic arterial plaque.
- P=0.01
- n=54
Why the study?
The degree of calcified atherosclerotic plaque formation in asthmatic patients compared to matched controls was not well characterized.
Does asthma affect the degree of calcified atherosclerotic plaque formation in patients over 50?
Comparison
Asthmatic patients vs age- and sex-matched controls
Design
Radiographic case-control study
Authors
Discussion
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Implication
Hypothesis-generating for reduced vascular calcification in older asthmatics; leaves open causal links and should not yet change practice.
Study Design
Type
Case-Control (n=54)
Structured PICO
Does asthma affect the degree of calcified atherosclerotic plaque formation in patients over 50?
P
Population
27 asthmatic patients over age 50 and age- and sex-matched controls evaluated for atherosclerotic arterial calcifications.
E
Exposure
Asthma (observational exposure)
C
Comparator
Age- and sex-matched controls without asthma
O
Outcome
Degree of calcified atherosclerotic plaque formation in the aorta and its major pelvic branches (iliac and hypogastric arteries) measured radiographicallysurrogate
Main Result
p-value: p=0.01
Asthmatic patients over 50 exhibit significantly less atherosclerotic arterial calcification compared to matched controls, which authors hypothesize may be related to elevated endogenous heparin-like material.
Cite This Study
Lasser et al. (1987) conducted a case-control in Asthma (n=54). Asthma vs. Age- and sex-matched controls was evaluated on Degree of calcified atherosclerotic plaque formation in the aorta and its major pelvic branches (p=0.01). Asthmatic patients over age 50 had significantly less calcified atherosclerotic plaque formation in the aorta, iliac, and hypogastric arteries compared to matched controls (P=0.01).