Key result
CHOP chemotherapy partially alleviates symptoms in CD5-positive pulmonary DLBCL despite CT disease progression.
Why the study?
Primary pulmonary diffuse large B-cell lymphoma is extremely rare with nonspecific clinical symptoms and poorly defined imaging features, necessitating further description for diagnosis and treatment.
Case Report (n=1)
This case report highlights the rare presentation of CD5-positive primary pulmonary diffuse large B-cell lymphoma with uncommon imaging features like consolidations and reverse halo sign.
Primary pulmonary diffuse large B-cell lymphoma (PPDLBCL) is extremely rare. Its clinical symptoms and signs are nonspe cific, and imaging features also have not yet been well-defined. Further description is important for the diagnosis and treatment of PPDLBCL. Herein, we reported a case of a patient who suffered from bilateral chest pain and dyspnea. Computed tomography (CT) of chest demonstrated bilateral lung mass, consolidations and reverse halo sign, while consolidations and reverse halo sign are uncommon according to previous reports. Tissue samples were taken by CT guided needle biopsy. The histological samples showed PPDLBCL. This case was special in view of positive expression of CD5. After the case was treated by cyclophosphamide pirarubicin vindesine dexamethasone (CHOP) chemotherapy for six courses, her clinical symptoms were partially alleviated, while CT showed progression disease. This case report highlights different imaging features and characteristics of molecular biology, and reviews study progress of PPDLBCL.
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Wang et al. (2016) conducted a case report in Primary pulmonary diffuse large B-cell lymphoma (PPDLBCL) (n=1). CHOP chemotherapy (cyclophosphamide pirarubicin vindesine dexamethasone) was evaluated on Clinical symptoms and CT imaging. Treatment with six courses of CHOP chemotherapy partially alleviated clinical symptoms in a patient with CD5-positive primary pulmonary diffuse large B-cell lymphoma, although CT showed disease progression.
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