Key result
High PDGF-B expression predicts ~195% worse disease-specific survival in resected non-GIST soft-tissue sarcomas.
Why the study?
The prognostic impact of platelet-derived growth factors and their receptors in non-GIST soft-tissue sarcomas with wide and nonwide resection margins was unclear.
Does high expression of PDGF-B and PDGFR-α predict worse disease-specific survival in patients with non-GIST soft-tissue sarcomas?
Cohort (n=249)
Does high expression of PDGF-B and PDGFR-α predict worse disease-specific survival in patients with non-GIST soft-tissue sarcomas?
High expression of PDGF-B and coexpression of PDGF-B and PDGFR-α identify a subgroup of non-GIST soft-tissue sarcoma patients with wide resection margins who have poor disease-specific survival.
High PDGF-B/PDGFR-α coexpression flags poor DSS despite wide margins in non-GIST STS; leaves open utility for risk stratification or targeted trials.
Background. Optimal treatment of nongastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) is resection with wide margins. This study investigates the prognostic impact of the angiogenesis-associated platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) in non-GIST STS patients with wide and nonwide resection margins. Method. Tumor samples and clinical data from 249 patients with non-GIST STS were obtained, and tissue microarrays were constructed for each specimen. Immunohistochemistry was used to evaluate the expression of PDGF-A, -B, -C, and -D and PDGFR-α and -β. Results. In the multivariate analysis of patients with wide resection margins, high expression of PDGF-B (P = .013, HR = 2.954, and 95% CI = 1.255-6.956) and the coexpression of PDGF-B and PDGFR-α (overall; P = .016, high-low/low-high; P = .051, HR = 2.678, 95% CI = 0.996-7.200, high/high; P = .004, HR = 3.930, 95% CI = 1.542-10.015) were independent negative prognostic markers for disease-specific survival. Conclusion. PDGF-B and the coexpression of PDGF-B and PDGFR-α are strong and independent prognostic factors in non-GIST STSs with wide resection margins.
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Kilvær et al. (2010) conducted a cohort in non-GIST soft-tissue sarcomas (n=249). High expression of PDGF-B vs. Low expression was evaluated on disease-specific survival (HR 2.954, 95% CI 1.255-6.956, p=0.013). High expression of PDGF-B independently predicted worse disease-specific survival in non-GIST soft-tissue sarcomas with wide resection margins (HR 2.954; 95% CI 1.255-6.956; P=0.013).
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