Synthesis of GalNGcα1-3GalNAcα disaccharide and its interaction with human blood antibodies

This is the authors' abstract. We don't add key points for this paper.

We have synthesized GalNGcα1-3GalNAcα disaccharide, a glycoloyl analogue of GalNAcα1-3GalNAcα known as the core 5 motif of mucin-type glycoproteins, and investigated how this structural variation affects the interaction with human natural antibodies. In contrast to the case of the Neu5NGc/Neu5NAc pair, the additional glycoloyl OH group in GalNGcα1-3GalNAcα markedly reduced the antigenicity of the GalNGcα moiety.