Key result
Elevated nonesterified fatty acids limit glucagon-stimulated hepatic glucose output by blunting glycogenolysis ~40%.
Why the study?
The effect of elevated nonesterified fatty acids on glucagon-stimulated hepatic glucose output and its components was not fully understood.
Population
18-h-fasted, pancreatic-clamped conscious dogs
Comparison
Glucagon infusion with peripheral Intralipid plus heparin (NEFA + GGN) vs glucagon infusion alone (GGN) and other controls
Design
Preclinical experimental study
Follow-up
3 hours
Authors
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Elevated NEFAs blunt early glucagon-driven hepatic glucose output in canines; leaves open relevance to human counterregulation.
Effect estimate: blunted by 40%
Absolute Event Rate: 3.8% vs 6%
Elevated nonesterified fatty acids limit the initial increase in glucagon-stimulated hepatic glucose output by blunting glycogenolysis in a canine model.
Grueter et al. (2006) studied 18-h-fasted, pancreatic-clamped conscious dogs. Peripheral Intralipid plus heparin infusion (NEFA elevation) vs. Glucagon alone, hyperglycemic, hyperglycemic-hyperlipidemic, and glycerol plus glucagon controls was evaluated on Net hepatic glycogenolysis (NHGLY) (blunted by 40%). Elevated nonesterified fatty acids limited the initial increase in glucagon-stimulated hepatic glucose output by blunting glycogenolysis by 40%.
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