Key result
Highest magnesium intake is linked to an ~11% lower total stroke risk versus lowest intake.
Why the study?
The effect of magnesium intake on stroke risk has been inconsistently reported and remains unclear due to contradictory results in previous studies.
Does higher magnesium intake reduce the incidence of stroke in individuals without current stroke?
Population
15 prospective cohort studies involving 18 cohorts
Comparison
Highest versus lowest magnesium intake categories
Design
Systematic review and meta-analysis of prospective cohort studies
Authors
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Higher magnesium intake was associated with lower stroke risk; leaves open preventive benefit pending RCTs.
Meta-Analysis (n=692,998)
Yes
Does higher magnesium intake reduce the incidence of stroke in individuals without current stroke?
Relative Risk: 0.89 (95% CI 0.83–0.94)
p-value: p=<0.001
Higher magnesium intake is associated with a significantly reduced risk of total and ischemic stroke in a dose-dependent manner.
Zhao et al. (2019) conducted a meta-analysis in Stroke (n=692,998). Magnesium intake vs. Lowest magnesium intake category was evaluated on Total stroke incidence (RR 0.89, 95% CI 0.83-0.94, p=<0.001). Comparing the highest magnesium intake category to the lowest, magnesium intake was associated with an 11% reduction in the risk of total stroke (RR 0.89).
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