Comparative Hormonal and immunoglobulin profiles of Aborted Women with or without toxoplasmsis

Background: Toxoplasmosis is a worldwide disease that causes abortions in human and animals.Objective: This study assumed that abortions due to toxoplama is associated with increased IgM and IgG immunoglobulins results from disrupting estrogen, progesterone, cortisol and prolactin hormones.Methods: Blood samples of T. gondii sero-positive (n = 25) and sero-negative (n = 10) aborted women at the three gestational trimesters were subjected to ELISA IgM and IgG serological assays and hormone assaying.Simple one way ANOVA was used to test the effect of trimester on hormone concentrations and independant sample t-test was used to study the effect the sero-typing.Results: Aborted Toxoplasma sero-positive women were younger (P=0.004) and had (P=0.0001)high IgG, IgM and estrogen (P=0.02)but low cortisol (P=0.029) and prolactin (P=0.005).Conclusion; the alterations in estrogen, cortisol and prolactin hormones possibly predispose latent opportunistic toxoplasmosis during pregnancy in carrier women.