The present article describes the history, organization, and funding of the Spanish SEN1500 network. The Spanish Neonatal Database SEN1500 was established in 2002. SEN1500 aims are to monitor the perinatal, neonatal, and follow-up outcomes, the socioeconomic environment and the quality of care delivered to very low birthweight infants, and since 2019 to all very preterm infants, admitted to the participant units. SEN1500 periodically produce detailed statistical reports for every unit with their own and pooled data. SEN1500 allows the participating units to identify areas of improvement through benchmarking within the network and between international networks. SEN1500 encourages perinatal-neonatal epidemiological research, with our own data or in collaboration with similar international networks such as the International Network for Evaluating Outcomes (iNeo) and the Latin-American based Red Neonatal del Cono Sur (NEOCOSUR). At the time of publication of this manuscript, this collaboration has resulted in nearly 50 peer-reviewed articles. In conclusion, the Spanish SEN1500 database has just come of age. Since its origin and throughout its development, it has proven to be a fundamental tool for evaluating the quality of care for the very premature or very low birth weight (VLBW) newborns both in our country and in the participating units, helping them improve in a sustained way. In addition, collaboration with other international networks has enhanced its ability to generate knowledge and has improved the quality of the SEN1500 network database itself.
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