Key result
High monocyte resistin mRNA expression is linked to ~42% lower flow-mediated vasodilation.
Why the study?
The role of resistin on metabolic and vascular homeostasis in humans, particularly its association with insulin resistance and endothelial function, is not well defined.
Cross-Sectional (n=54)
Absolute Event Rate: 4.3% vs 7.4%
p-value: p=0.003
Monocyte resistin mRNA expression is independently associated with reduced flow-mediated vasodilation, suggesting it may serve as an in vivo marker of endothelial dysfunction in metabolic syndrome.
Monocyte resistin mRNA associates with reduced FMV in metabolic syndrome; leaves open causal role in endothelial dysfunction pending prospective trials.
BACKGROUND: Resistin could be the linkage between the adipose tissue and the insulin resistance. In humans, the role of resistin on metabolic and vascular homeostasis is not well defined. The aim of this study was to investigate the possible association between resistin expression and insulin resistance. METHODS AND RESULTS: We evaluated the relationship between monocyte expression of mRNA and anthropometric and metabolic parameters of insulin resistance. We focused on the potential role of resistin on endothelial function. Thirty-nine patients with metabolic syndrome (MS) and clinically free from cardiovascular disease, and 15 healthy subjects were included in this study. All subjects underwent clinical examination, assessment of haematochemical parameters, bioimpedentiometry, measurement of monocyte resistin mRNA and of brachial-artery flow-mediated vasodilation (FMV). Patients with MS showed higher levels of interleukin-6 (IL; 2.1 +/- 1.2 vs. 1.2 +/- 0.9 pg/mL, P < 0.05) and reduced FMV (5.4 +/- 3.9 vs. 8.3 +/- 3.1%, P < 0.05). The subjects were divided into two groups: (i) subjects with high expression mRNA resistin levels and (ii) subjects with low or not detectable; Group 1 was younger (50 +/- 13 vs. 59 +/- 11 years, P = 0.01), showed higher IL-6 values (2.3 +/- 1.2 vs. 1.6 +/- 1.2, P = 0.03) and lower values of FMV (4.3 +/- 2.8 vs. 7.4 +/- 3.9%, P = 0.003). With univariate analysis monocyte mRNA showed a significant positive correlation with waist circumference (r = 0.27, P < 0.05) and IL-6 (r = 0.26, P < 0.05) and a negative correlation with FMV (r = -0.38, P < 0.005). With multivariate regression analysis brachial-artery diameter, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, IL-6 and RNAm resistin expression were independent predictors of reduced FMV. CONCLUSIONS: mRNA resistin negatively influences FMV, and is a possible in vivo index of endothelial dysfunction.
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Lupattelli et al. (2007) conducted a cross-sectional in Metabolic syndrome (n=54). High monocyte resistin mRNA expression vs. Low or not detectable monocyte resistin mRNA expression was evaluated on Brachial-artery flow-mediated vasodilation (FMV) (p=0.003). High monocyte resistin mRNA expression was associated with significantly lower flow-mediated vasodilation compared to low or undetectable expression (4.3% vs 7.4%, P=0.003).
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