Key result
SO2 inhalation induces concentration-dependent nonadrenergic noncholinergic bronchodilation in bronchoconstricted cats.
Why the study?
The mechanisms underlying bronchodilation induced by high concentrations of sulfur dioxide in bronchoconstricted airways were unclear.
Population
Anesthetized cats bronchoconstricted with continuous 5-hydroxytryptamine infusion
Comparison
10 breaths of SO2 (100-1,000 ppm) vs pretreatment with atropine, propranolol, hexamethonium, tetrodotoxin, indomethacin, cromolyn sodium, or acidic aerosols
Design
Preclinical experimental study
Authors
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Supports intrinsic NANC bronchodilator pathways in feline airways; hypothesis-generating for human disease with no clinical implications yet.
High concentrations of SO2 induce a nonadrenergic noncholinergic bronchodilator response in artificially bronchoconstricted cats, suggesting an intrinsic inhibitory system in feline airways.
Thompson et al. (1990) studied artificially bronchoconstricted. Sulfur dioxide (SO2) vs. Acidic aerosols was evaluated on bronchodilation. Administration of 10 breaths of SO2 (100-1,000 ppm) to artificially bronchoconstricted cats induced a concentration-dependent nonadrenergic noncholinergic bronchodilation.
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