Key result
Aortic valve pathology reveals severe calcific sclerosis and hyaline cartilage, suggesting mesenchymal cartilaginous transformation.
Why the study?
The mechanisms of abnormal repair in valvular tissue damaged by calcific aortic stenosis are not well characterized.
Case Report (n=1)
Cartilaginous metaplasia can occur in calcific aortic valve disease, representing an abnormal repair mechanism of damaged valvular tissue.
Does not inform aortic stenosis management; leaves open the frequency and clinical relevance of valvular cartilaginous metaplasia.
In a 49-year-old man, symptoms of aortic valve stenosis developed that required surgical intervention with valve replacement. Pathologic examination of the valve showed severe calcific aortic sclerosis and foci of hyaline cartilage. The authors believe that these foci are secondary to cartilaginous transformation of mesenchymal valvular tissue. This represents abnormal repair of valvular tissue damaged, in this case, by the nodular calcific process of calcific aortic stenosis.
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Groom et al. (1990) conducted a case report in Calcific aortic valve disease (n=1). Calcific aortic stenosis was evaluated on Pathologic examination of the valve. Pathologic examination of a replaced aortic valve revealed severe calcific aortic sclerosis and foci of hyaline cartilage, suggesting cartilaginous transformation of mesenchymal valvular tissue.
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