Key result
Histochemical analysis of 15 surgically removed calcified aortic valves revealed that proteolysis, ineffective remodeling, and calcification are fundamental sequential steps of tissue degeneration.
Population
15 cases of calcified aortic valves surgically removed for acquired steno-insufficiency
Design
Case_series
Authors
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Does not alter aortic stenosis management; leaves open sequential targets for mechanistic research.
Observational (n=15)
Histological analysis of calcified aortic valves reveals a sequential degenerative process involving proteolysis, ineffective remodeling, and calcification, which can be distinguished from endocarditis and rheumatic lesions using conventional techniques.
Manenti et al. (2015) conducted an observational in Calcified aortic valve (n=15). Histochemical analysis was evaluated on Histological and pathogenetic mechanisms of aortic valve calcification. Histochemical analysis of 15 surgically removed calcified aortic valves revealed that proteolysis, ineffective remodeling, and calcification are fundamental sequential steps of tissue degeneration.
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