Key result
Floppy mitral valve classification distinguishes symptoms of mitral regurgitation from FMV syndrome.
Why the study?
Floppy mitral valve/mitral valve prolapse is a complex entity lacking a precise definition and a diagnostic approach that accounts for its multiple genotypes and phenotypes.
Answers are grounded in this paper and cite their sources.
This review emphasizes diagnosing floppy mitral valve rather than just mitral valve prolapse and proposes a clinical classification separating FMV/MVP syndrome from FMV/MVP with significant mitral regurgitation.
Few disorders have evoked more interest and controversy in cardiology over recent centuries than floppy mitral valve (FMV)/mitral valve prolapse (MVP). FMV/MVP is a complex entity with multiple genotypes and phenotypes in which the clinical manifestations may not be directly related to the severity of mitral regurgitation. Furthermore, there is a lack of a precise definition of this complex entity. This review emphasises a diagnostic approach based mostly on FMV rather than solely on MVP, which frequently may be a non-specific finding. In addition, a clinical classification of FMV/MVP is presented that separates patients with symptoms not directly related to the severity of mitral regurgitation (referred to as FMV/MVP syndrome) from those in whom symptoms are directly related to mitral regurgitation and its complications. In the future, genetic variants will likely be incorporated into the diagnostic classification and management of this complex entity as this odyssey continues.
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Boudoulas et al. (2026) conducted a review in Floppy Mitral Valve / Mitral Valve Prolapse. Floppy mitral valve (FMV) should be the primary diagnostic focus rather than solely mitral valve prolapse, with a clinical classification separating symptoms related to mitral regurgitation from those of FMV syndrome.
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