Key result
Every 10-fold increase in Torque teno virus load is linked to ~26% lower allograft rejection risk.
Why the study?
The challenge of balancing immunosuppressive therapy to prevent organ rejection without promoting infection after kidney transplantation motivates investigation of TTV loads as a marker of functional immunity.
Does Torque teno virus (TTV) load predict the risk of common viral infection and allograft rejection in kidney transplantation recipients?
Population
389 kidney transplantation recipients
Comparison
TTV load levels predicting allograft rejection versus viral infections (BKPyV and CMV)
Design
Retrospective cohort study with repeated TTV measurements and joint survival analysis
Follow-up
One year
Authors
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TTV load may support rejection-risk stratification in kidney transplant recipients; leaves open its utility for guiding immunosuppression without raising viral risk.
Cohort (n=389)
Does Torque teno virus (TTV) load predict the risk of common viral infection and allograft rejection in kidney transplantation recipients?
Hazard Ratio: 0.74 (95% CI 0.71–0.76)
TTV load kinetics predict allograft rejection in kidney transplantation recipients, suggesting its potential utility as a biomarker to guide optimal immunosuppressive drug dosage.
Rijn et al. (2021) conducted a cohort in Kidney transplantation (n=389). Torque teno virus (TTV) load vs. Lower TTV load was evaluated on Allograft rejection (HR 0.74, 95% CI 0.71-0.76). Every 10-fold increase in Torque teno virus load was associated with a decreased risk of allograft rejection (HR 0.74; 95% CI 0.71-0.76), but not BKPyV or CMV viremia.
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