Key result
Each log increase in TTV load decreased odds for rejection (OR 0.78; 95% CI 0.62-0.97; P=0.027) and increased odds for infection (OR 1.11; 95% CI 1.06-1.15; P<0.001) in kidney transplant recipients.
Why the study?
Previous studies proposed torque teno virus quantification for risk stratification of graft rejection and infection in kidney transplant recipients.
Does torque teno virus (TTV) load predict the risk of graft rejection and infection in kidney transplant recipients?
Population
386 consecutive kidney transplant recipients
Comparison
Longitudinal per-protocol monitoring of plasma TTV load
Design
Prospective observational trial
Follow-up
12 months posttransplant
Authors
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May support TTV load as a noninvasive rejection marker; hypothesis-generating and requires prospective validation before clinical use.
Observational (n=386)
Does torque teno virus (TTV) load predict the risk of graft rejection and infection in kidney transplant recipients?
Odds Ratio: 0.78 (95% CI 0.62–0.97)
p-value: p=.027
Monitoring TTV load in kidney transplant recipients can stratify the risk of graft rejection and infection, with an optimal target range of 1 × 10^6 to 1 × 10^8 copies/mL.
Doberer et al. (2020) conducted an observational in Kidney transplant recipients (n=386). Plasma TTV load was evaluated on Rejection diagnosed by indication biopsy (OR 0.78, 95% CI 0.62-0.97, p=.027). Each log increase in TTV load decreased odds for rejection (OR 0.78; 95% CI 0.62-0.97; P=0.027) and increased odds for infection (OR 1.11; 95% CI 1.06-1.15; P<0.001) in kidney transplant recipients.
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