Key result
Lower TTV DNA load is linked to ~7-fold higher acute rejection odds but poorly predicts infection.
Why the study?
The diagnostic accuracy of torque teno virus viral DNA load for acute rejection and infection after kidney transplantation has not been evaluated.
Does Torque teno virus (TTV) viral DNA load accurately predict acute rejection and infection in kidney transplant recipients?
Comparison
TTV viral DNA load in patients with acute rejection or infection versus those without
Design
Systematic review and meta-analysis
Authors
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May modestly aid rejection risk stratification but not infection after kidney transplant; leaves open clinical utility pending prospective validation.
Meta-Analysis
Does Torque teno virus (TTV) viral DNA load accurately predict acute rejection and infection in kidney transplant recipients?
Mean Difference: -0.74
p-value: p=<0.01
TTV viral DNA load may serve as a modest indicator for risk stratification of acute rejection after kidney transplantation, but has poor accuracy for discriminating posttransplant infection.
Zeng et al. (2023) conducted a meta-analysis in Kidney transplantation. Torque teno virus (TTV) DNA load vs. Patients without acute rejection or infection was evaluated on TTV viral DNA load difference in acute rejection (MD -0.74, p=<0.01). Lower Torque teno virus DNA load was associated with acute rejection (MD -0.74, p<0.01) with a diagnostic odds ratio of 6.74, but showed poor accuracy for discriminating posttransplant infection.
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