Key result
Inhaled nitroglycerine reduces PA pressures ~50% in two cases of severe PH and acute RHF.
Why the study?
Life-threatening right heart failure and shock due to severe pulmonary hypertension may not respond to traditional treatments, necessitating alternative therapies.
Does inhaled nitroglycerine improve stabilization in patients with severe pulmonary hypertension and impending acute right ventricular failure?
Case Report (n=2)
Does inhaled nitroglycerine improve stabilization in patients with severe pulmonary hypertension and impending acute right ventricular failure?
Inhaled nitroglycerine may be a practical and accessible alternative to inhaled nitric oxide for acute stabilization of severe pulmonary hypertension and right heart failure in resource-limited settings.
May offer accessible alternative for acute PH stabilization in limited settings; hypothesis-generating and requires prospective validation.
In this review, two cases of severe pulmonary hypertension of different classes that have been successfully treated using inhaled nitroglycerine are presented. In a community hospital setting and in cases of life-threatening right heart failure and shock not responding to simple traditional treatments, thought should be given to the use of inhaled nitroglycerine. Inhaled nitroglycerine is practical, cheap, and readily available in any hospital without reconstitution. This approach may allow for the treatment, or at least temporary stabilisation, of these patients until transferred to a tertiary care facility.
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Sorour et al. (2020) conducted a case report in Severe pulmonary hypertension and impending acute right ventricular failure (n=2). Inhaled nitroglycerine was evaluated on Reduction in pulmonary arterial pressure. Inhaled nitroglycerine successfully reduced pulmonary arterial pressures by more than 50% within 6 hours in two cases of severe pulmonary hypertension and acute right heart failure.
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