Key result
Unilateral IMC tumor uptake occurs in 46% of benign adrenocortical adenomas, linked to higher cortisol.
Why the study?
The role of 131I-6 beta-iodomethylnorcholesterol scintigraphy in specifying the functional autonomy of benign adrenocortical adenomas was uncertain.
Does 131I-6 beta-iodomethylnorcholesterol scintigraphy correlate with adrenocortical function in patients with unilateral adrenocortical incidentalomas?
Observational (n=35)
Does 131I-6 beta-iodomethylnorcholesterol scintigraphy correlate with adrenocortical function in patients with unilateral adrenocortical incidentalomas?
Absolute Event Rate: 46% vs 54%
Unilateral 131I-6 beta-iodomethylnorcholesterol uptake correlates with functioning adenomas with various degrees of autonomy, suggesting its utility in screening for subclinical Cushing's adenomas.
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Unilateral IMC uptake signals subclinical autonomy in benign incidentalomas; leaves open its screening utility pending prospective validation.
Bardet et al. (1996) conducted an observational in Adrenocortical incidentalomas (n=35). Unilateral 131I-6 beta-iodomethylnorcholesterol (IMC) uptake vs. Bilateral IMC uptake was evaluated on Prevalence of unilateral vs bilateral IMC uptake. Unilateral 131I-6 beta-iodomethylnorcholesterol tumour uptake was found in 46% of patients with benign adrenocortical adenomas and was associated with lower ACTH (P=0.05) and higher cortisol (P=0.02).
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