Fibromyalgia and Interleukin-2 Therapy for Malignancy

Letters and Corrections1 June 1988Fibromyalgia and Interleukin-2 Therapy for MalignancyDANIEL J. WALLACE, M.D., KIM MARGOLIN, M.D., PAM WALLER, R.N.DANIEL J. WALLACE, M.D., KIM MARGOLIN, M.D., PAM WALLER, R.N.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-909_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the study by Denicoff and colleagues (1) on the neuropsychiatric effects of treatment with interleukin-2 with or without lymphokine-activated killer cells. The authors observed that most patients had decreased energy, fatigue, anorexia, malaise, and sleep disturbances. In neither this report nor the group's most recent toxicity survey is there any mention of musculoskeletal complications, even though such symptoms were briefly discussed previously (2, 3). The City of Hope National Medical Center is one of six collaborating centers using variations of the Rosenberg protocol. Many of the patients we have treated were observed to...References1. DENICOFFRUBINOWPAPA KDM. The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells. Ann Intern Med. 1987;107:293-300. LinkGoogle Scholar2. ROSENBERGLOTZEMUUL SML. A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med. 1987;316:889-97. CrossrefMedlineGoogle Scholar3. LOTZEMATORYETTINGHAUSEN MYS. In vivo administration of purified human interleukin 2: II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL2. J Immunol. 1985;135:2865-75. MedlineGoogle Scholar4. GOLDENBERG D. Fibromyalgia syndrome: An emerging but controversial condition. JAMA. 1987;257:2782-7. CrossrefMedlineGoogle Scholar5. PETERWALLACE JD. Abnormalities in immunologic regulation in the primary fibromyalgia syndrome [Abstract]. Arthritis Rheum. 1988;31: [In press]. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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I. Medical and pathophysiological aspectsImmunomodulating agentsCytokines and immune regulation in patients with fibrositisFibromyalgia: The Clinical Syndrome 1 June 1988Volume 108, Issue 6Page: 909-909KeywordsCellsFatigueFibromyalgiaSleepToxicity Issue Published: 1 June 1988 PDF downloadLoading ...