Theophylline was entrapped in ethyl cellulose microspheres by a water/oil/water emulsification-solvent evaporation method. Aqueous solution of drug was emulsified into a solution of ethyl cellulose in toluene, containing polyisobutylene as protective colloid, followed by emulsification of this primary emulsion into an external aqueous phase to form a water/oil/water emulsion. Microspheres was formed after solvent evaporation and precipitation of ethyl cellulose. In vitro dissolution profile and effect of polyisobutylene on it were studied.
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Sudip Das (1991) studied this question.
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