Key result
Biomechanical PDE framework simulates atherosclerotic plaque evolution to output images resembling enhanced IVUS.
Why the study?
A quantitative framework to describe the evolution of atherosclerotic plaque integrating biological and biomechanical factors was needed.
A proposed quantitative framework using PDEs and biomechanical modeling can simulate atherosclerotic plaque evolution and generate outputs similar to intravascular ultrasound images.
May support computational plaque modeling research; leaves open clinical validation before any practice consideration.
In this article, we propose a quantitative framework to describe the evolution of atherosclerotic plaque. We use partial differential equations (PDEs) with macrophages, necrotic cells, oxidized lipids, oxygen concentration, and PDGF as primary variables coupled to a biomechanical model to describe vessel growth. A feature of our method is that it outputs color-coded vessel sections corresponding to regions of the plaque that are necrotic and fibrous, qualitatively similar to images generated by enhanced intravascular ultrasound.
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Mirzaei et al. (2020) studied Atherosclerotic plaque. Quantitative framework using partial differential equations and a biomechanical model was evaluated on Simulation of atherosclerotic plaque evolution and vessel growth. A quantitative framework using partial differential equations and a biomechanical model simulated atherosclerotic plaque evolution, outputting images similar to enhanced intravascular ultrasound.
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