Why the study?
Prostaglandins play an important role in platelet-vessel wall interaction and the effect of cyclooxygenase inhibition by acetylsalicylic acid on this interaction requires clarification.
Acetylsalicylic acid induces a rapid but transient decrease in thromboformation, likely mediated by the balance of cyclic endoperoxides and prostacyclin.
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Rapid but transient antithrombotic effect with local ASA; leaves open endoperoxide/PGI2 ratio as driver of thromboformation.
Prostaglandins play an important role in the platelet-vessel wall interaction. Acetylsalicylic acid inhibits the cyclooxygenase activity within the vessel wall. Continuous superfusion with acetylsalicylic acid induces a rapid, but evanescent decrease in thromboformation. The trigger mechanism involved could be related to the ratio of cyclic endoperoxides (PGG2 and PGH2) versus prostacyclin (PGI2).
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Bourgain et al. (2009) studied Platelet-vessel wall interaction. Acetylsalicylic acid was evaluated on Thromboformation.
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