Key result
Novel rationally designed RNA ligands demonstrate cooperative interaction with HIV-1 TAR RNA.
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Novel RNA ligands were designed and synthesized to cooperatively bind HIV-1 TAR RNA.
We report here the rational design and the synthesis of a new series of RNA ligands. These molecules are constituted of various binding motifs that interact cooperatively with HIV-1 TAR RNA, used as a model.
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Duca et al. (2010) studied this question. Novel rationally designed RNA ligands composed of various binding motifs demonstrated cooperative interaction with HIV-1 TAR RNA.
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