Key result
Ramipril matches atenolol in reducing systolic and diastolic blood pressure in mild-to-moderate hypertension.
Why the study?
The comparative efficacy of ramipril versus atenolol in controlling mild-to-moderate hypertension was evaluated in a randomized trial.
Does ramipril reduce blood pressure as effectively as atenolol in patients with mild-to-moderate hypertension?
RCT (n=92)
Double-blind
parallel-group
Yes
Does ramipril reduce blood pressure as effectively as atenolol in patients with mild-to-moderate hypertension?
Ramipril and atenolol are equally effective in reducing and controlling mild-to-moderate hypertension.
Both remain appropriate first-line choices for mild-to-moderate hypertension; confirms equivalence between ACE inhibitor and beta-blocker.
This trial was a multicenter, double-blind, randomized, parallel-group, variable-dose study comparing ramipril with atenolol, and incorporating a 4-week run-in period on placebo. A total of 92 patients suffering from mild to moderate hypertension were randomized to the trial. Following a 4-week run-in period on placebo, newly diagnosed patients were only continued if their blood pressure remained within the defined range throughout the placebo run-in period. Known hypertensive patients who were safely switched to the trial therapy were only continued if their blood pressure was within the defined range at the end of this placebo washout period. An analysis of the data at baseline showed no statistical differences between treatment groups. Both systolic and diastolic blood pressures were significantly reduced from baseline in each group, but there were no differences between treatments. The study showed that ramipril and atenolol were both successful at reducing and controlling mild-to-moderate hypertension, but it showed no difference between treatments.
No takes yet. Share an insight, caveat, or question.
Lenox‐Smith et al. (1991) conducted an RCT in mild to moderate hypertension (n=92). Ramipril vs. Atenolol was evaluated on reduction in systolic and diastolic blood pressures. Ramipril and atenolol both significantly reduced systolic and diastolic blood pressures in patients with mild-to-moderate hypertension, with no difference between treatments.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: