Preclinical investigation reveals microbiota-gut-brain axis disruption after neonatal enteropathogenic infection, indicating a biological driver of chronic cognitive and developmental impairment.
Diarrheal diseases are a leading cause of death in children under the age of 5 years worldwide. Repeated early-life exposures to diarrheal pathogens can result in comorbidities including stunted growth and cognitive deficits, suggesting an impairment in the microbiota-gut-brain (MGB) axis.
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Hennessey et al. (2021) studied this question.
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