Answers are grounded in this paper and cite their sources.
Paraganglioma, HIF-2α, and Cyanotic Heart Disease Four of five patients with paragangliomas and pheochromocytomas who had received a diagnosis of congenital cyanotic heart disease had mutant HIF-2α. This contrasts with the prevalence of mutant HIF-2 in these tumor types in the absence of cyanotic heart disease (6 to 10%).
No takes yet. Share an insight, caveat, or question.
Vaidya et al. (2018) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: