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September 2, 2010Basic & Clinical Pharmacology & ToxicologyOpen Access

Stereo-Selective Metabolism of Methadone by Human Liver Microsomes and cDNA-Expressed Cytochrome P450s: A Reconciliation

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Authors

YCYan ChangShandong UniversityWFWenfang B. FangUniversity of UtahSLShen LinHenan University of Science and Technology

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Chang et al. (2010) studied this question.

synapsesocial.com/papers/6aaf5fdeec6de5f9fc398887https://doi.org/10.1111/j.1742-7843.2010.00628.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of CYP2B6 in Stereoselective Human Methadone Metabolism2008 · 192 citations
  2. 2Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment2005 · 227 citations
  3. 3Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport2009 · 83 citations