Key result
Automated solid-phase synthesis efficiently incorporates a phosphoramidite of the remdesivir precursor GS-441524 into RNA.
Why the study?
Efficient synthesis methods for incorporating GS-441524, the nucleoside precursor of remdesivir, into RNA are needed to enable studies of viral polymerases.
The study provides a method to synthesize RNA containing the remdesivir precursor GS-441524, enabling further studies of viral polymerases.
Enables RNA studies with remdesivir; leaves open mechanistic insights into viral polymerases pending validation.
Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and its incorporation into RNA using automated solid-phase RNA synthesis.
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Moorthy et al. (2021) studied this question. A phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, was efficiently synthesized and incorporated into RNA using automated solid-phase RNA synthesis.
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