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Organic molecules of different complexity are aligned by a DMSO-compatible gel in such a way that C–H dipolar couplings up to 29 Hz are observed. This paves the way to the simultaneous determination of conformation and configuration of organic compounds by NMR spectroscopy and thus enables the determination of the stereochemistry of natural products (e.g. hormaomycin, see picture) that cannot be crystallized.
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Haberz et al. (2004) studied this question.
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