Key result
rs10757278 GG genotype is linked to ~142% higher odds of carotid plaque in females only.
Why the study?
The association of the 9p21 locus rs10757278 polymorphism with carotid atherosclerosis, especially in a gender-specific manner, was rarely investigated.
Is the rs10757278 A/G polymorphism associated with carotid plaque presence in advanced carotid atherosclerosis?
Case-Control (n=803)
Is the rs10757278 A/G polymorphism associated with carotid plaque presence in advanced carotid atherosclerosis?
The rs10757278 GG genotype at the 9p21 locus is associated with advanced carotid atherosclerosis in a gender-specific manner, specifically increasing risk in females.
May support gender-specific 9p21 risk for carotid plaque in females; hypothesis-generating and requires prospective validation before clinical use.
Single nucleotide polymorphisms from the chromosome locus 9p21 are reported to carry a risk for various cardiovascular diseases. One of the lead single nucleotide polymorphisms, rs10757278, was mostly investigated in association with coronary artery disease but rarely with carotid atherosclerosis. In this study, we aimed to analyze the association of rs10757278 A/G polymorphism with carotid plaque presence in advanced carotid atherosclerosis. The study included 803 participants, 486 patients with high-grade stenosis (>70%) who were undergoing carotid endarterectomy and 317 controls from Serbian population. Genotypes were determined using the real-time polymerase chain reaction. According to the recessive model of inheritance, GG genotype was significantly and independently associated with carotid plaque in females only (odds ratio 2.42, CI = 1.20-4.90, P = 0.013). Odds ratio was adjusted for age, body mass index, hypertension, TC, LDLC, HDLC and TG, and P value was corrected for multiple comparisons. Our preliminary findings suggest a gender-specific association of rs10757278 polymorphism with carotid plaque. Further studies on larger sample and in genetically and environmentally similar populations are needed.
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Životić et al. (2016) conducted a case-control in Advanced carotid atherosclerosis (n=803). rs10757278 GG genotype vs. Non-GG genotypes was evaluated on Carotid plaque presence (OR 2.42, 95% CI 1.20-4.90, p=0.013). The rs10757278 GG genotype was significantly and independently associated with the presence of carotid plaque in females only (OR 2.42; 95% CI 1.20-4.90; P=0.013).
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