Key result
The rs10757278 G allele is linked to ~44% higher CAD risk in a Saudi population.
Why the study?
Few studies have investigated the association of the rs10757278 polymorphism with coronary artery disease in the Saudi population.
Is the rs10757278 polymorphism associated with an increased risk of coronary artery disease in a Saudi population?
Case-Control (n=688)
Is the rs10757278 polymorphism associated with an increased risk of coronary artery disease in a Saudi population?
Odds Ratio: 1.44 (95% CI 1.15–1.8)
p-value: p=0.001
The rs10757278 polymorphism on chromosome 9p21 is significantly associated with an increased risk of coronary artery disease in the Saudi population.
May support CAD risk assessment in Saudis; extends 9p21 evidence but remains hypothesis-generating and should not change practice.
PURPOSE: Coronary artery disease (CAD) is one of the most important leading causes of morbidity and mortality worldwide. Few studies have been carried out in the Saudi population regarding the association of rs10757278 polymorphism with CAD. This study aimed to investigate the association of the rs10757278 polymorphism with CAD in Saudi population. MATERIALS AND METHODS: In this case-control study, we recruited 437 patients with CAD and 251 cross-matched healthy controls and performed polymorphism genotyping for rs10757278 using a polymerase chain reaction followed by a restriction fragment length polymorphism analysis. RESULTS: The G allele (OR-1.44; 95% CI: 1.15-1.80; p=0.001), as GG (OR-2.13; 95% CI: 1.35-3.36; p=0.0009), in the dominant (OR-1.47; 95% CI: 1.03-2.10; p=0.03) and recessive mode (OR-1.84; 95% CI: 1.26-2.70; p=0.001) of inheritance showed a high-risk association. A disease stratified risk analysis was conducted and comparisons were made using an ANOVA analysis. Diabetes showed a risk association (p=0.001). However, a regression analysis confirmed that for the CAD cases, there was an association between the GG genotype and diabetes (p=0.005). CONCLUSION: The results of this study suggest that the polymorphism rs10757278 is related to a high risk of CAD in a Saudi population.
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Bogari et al. (2021) conducted a case-control in Coronary artery disease (CAD) (n=688). rs10757278 polymorphism (G allele) vs. Healthy controls was evaluated on Coronary artery disease (OR 1.44, 95% CI 1.15-1.80, p=0.001). The rs10757278 G allele was significantly associated with a higher risk of coronary artery disease in a Saudi population (OR 1.44; 95% CI 1.15-1.80; p=0.001).
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