Key result
SNPs rs2383206 and rs10757278 are linked to 2- and 3-vessel coronary disease severity.
Why the study?
Common gene variants have been related to CAD, but their relationship to CAD severity is not completely elucidated.
Do specific gene variants predict CAD severity in the Saudi Arab population?
Case-Control (n=520)
Do specific gene variants predict CAD severity in the Saudi Arab population?
p-value: p=0.003 and 0.006
The SNPs rs10757278 and rs2383206 are associated with angiographic severity of coronary artery disease in the Saudi Arab population.
Should not change CAD management; hypothesis-generating for genetic severity prediction in Saudi Arabs.
Background. Different common gene variants were related to coronary artery disease (CAD) in many studies. Yet, the relation of these loci to the severity of CAD is not completely elucidated. Methods. We enrolled 520 subjects (315 CAD cases and 205 controls). CAD presence and extension were assessed by coronary angiography (CAG). Genotyping of five SNPs (namely, rs2230806 (1051G > A) in ABCA1 on chromosome 9, rs2075291 (553G > T) in ApoA5 on chromosome 11, rs320 in LPL on chromosome 8 intron (T → G at position 481), rs10757278 (c.22114477A > G), and rs2383206 (c.22115026 A > G) on chromosome 9p21 locus) was performed by allele-specific PCR. The degree and site of arterial lesions were used to classify patients, tested for association with CAD severity, and related to allele dosage. Results. The polymorphisms rs2383206 and rs10757278 showed significant associations with 2- and 3-vessel coronary disease (p =0.003 and 0.006, respectively). The homozygous GG genotypes of rs10757278 was associated with higher frequency of left anterior descending (LAD), right coronary artery (RCA) and left circumflex (LCX) diseases (p =0.002, 0.016 and 0.002, respectively). The GG genotypes of rs2383206 were found in higher percentage in patients with left main (LM) trunk and left circumflex (LCX) diseases ( <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>p</a:mi> <a:mo>=</a:mo> <a:mn>0.013</a:mn> </a:math> and 0.002, respectively). Conclusion. SNPs rs10757278 and rs2383206 allele dosage could predict CAD severity in the Saudi Arab population.
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Bogari et al. (2021) conducted a case-control in Coronary Artery Disease (n=520). Genotyping of 5 SNPs (rs2230806, rs2075291, rs320, rs10757278, rs2383206) vs. Controls was evaluated on Association with CAD severity (2- and 3-vessel coronary disease) (p=0.003 and 0.006). The SNPs rs2383206 and rs10757278 were significantly associated with 2- and 3-vessel coronary disease severity (p=0.003 and p=0.006, respectively).
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