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(1) Contrary to Brakefield, and in agreement with Quick, we find that in humans an appreciable quantity of benzoic acid is excreted as the glucuronide. The ingestion of 5, 6, and 7 g of benzoic acid leads to an excretion of some 5% in the form of its glucuronide. The ingestion of 8 g gives a higher figure (7.7%). (2) The maximum excretion occurs in the first 3 hours. Detoxication by glucuronic acid is complete in 9 to 15 hours, depending on the amount of benzoic acid ingested.
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Wagreich et al. (1940) studied this question.
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