Key result
P2Y receptors exhibit both anabolic and catabolic bone functions, complicating their potential as pharmacological targets.
Why the study?
The exact roles of P2Y receptors in bone homeostasis are not entirely clear, particularly their dual anabolic and catabolic functions.
P2Y receptors have dual anabolic and catabolic roles in bone biology, presenting a challenge for pharmacological targeting in bone-wasting diseases.
P2Y receptors, including eight subtypes, are G protein-coupled receptors that can be activated by extracellular nucleotides. Nearly all P2Y receptors are expressed in bone cells, suggesting their involvements in bone physiology and pathology. However, their exact roles in bone homeostasis are not entirely clear. Therefore, this mini review summarizes new research developments regarding individual P2Y receptors and their roles in bone biology, particularly detailing those which execute both anabolic and catabolic functions. This dual function has highlighted the conundrum of pharmacologically targeting these P2Y receptors in bone-wasting diseases. Further research in finding more precise targeting strategy, such as promoting anabolic effects via combining with physical exercise, should be prioritized.
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Zhou et al. (2022) conducted a review in Bone homeostasis and pathology. P2Y receptor modulation was evaluated. P2Y receptors exhibit both anabolic and catabolic functions in bone cells, complicating their potential as pharmacological targets for bone-wasting diseases.
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