Key result
Levobupivacaine matches bupivacaine safety and provides comparable pediatric orthopedic analgesia at lower concentrations than ropivacaine.
Why the study?
Levobupivacaine is increasingly used for pediatric orthopedic and traumatology anesthesia, but comparative data on its safety and analgesic efficacy versus bupivacaine and ropivacaine are needed.
Does levobupivacaine provide safe and effective analgesia compared to bupivacaine and ropivacaine in children undergoing orthopedic and traumatology interventions?
Does levobupivacaine provide safe and effective analgesia compared to bupivacaine and ropivacaine in children undergoing orthopedic and traumatology interventions?
Levobupivacaine is a safe and effective alternative to bupivacaine and ropivacaine for regional anesthesia in pediatric orthopedics and traumatology.
Answers are grounded in this paper and cite their sources.
May support levobupivacaine in pediatric regional anesthesia; leaves open need for randomized confirmation.
Levobupivacaine is an amide anesthetic, levorotatory isomer of bupivacaine. This literature review aimed to present the possibilities of levobupivacaine in the implementation of blockades for anesthesia in traumatology and orthopedics in children. Levobupivacaine is widely used for analgesia for orthopedic interventions in adults and has become an alternative to the less safe bupivacaine. The actions of levobupivacaine, bupivacaine, and ropivacaine in the implementation of neuroaxial and peripheral blockades, and the infiltration of postoperative wounds in children were compared in the present study. Levobupivacaine has been confirmed to be safe compared with bupivacaine in pediatric patients. Studies in children of different ages comparing levobupivacaine and ropivacaine, used for anesthesia in traumatology and orthopedics, indicate the same or greater analgesic potential of levobupivacaine, with a similar level of safety. Compared with ropivacaine, levobupivacaine provides comparable pain relief at lower concentrations. The presented clinical data of levobupivacaine use in children allow the expansion of the indications for anesthesia in orthopedics and traumatology. Clinical research should be continued to compare the effectiveness of different concentrations of levobupivacaine and ropivacaine in larger groups of pediatric patients. Relevant papers were obtained by searching PubMed and Scopus databases.
No takes yet. Share an insight, caveat, or question.
Ulrikh et al. (2018) conducted a review in Pain management in pediatric orthopedics and traumatology. Levobupivacaine vs. Bupivacaine or ropivacaine was evaluated. Levobupivacaine is a safe alternative to bupivacaine and provides comparable or greater pain relief at lower concentrations than ropivacaine for regional anesthesia in pediatric orthopedics.
Synapse has enriched 10 related papers. Consider them for comparative context: